• Western blot analysis of the lysates from HT-29 cells using HCN2 antibody.
  • Western blot analysis of lysates from Jurkat cells, using HCN2 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-HCN2 antibody (491-540 aa) (STJ93476)

SKU:
STJ93476

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (491-540 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HCN2
Gene ID: 610
Uniprot ID: HCN2_HUMAN
Immunogen Region: 491-540 aa
Specificity: HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HCN2 at the amino acid range 491-540
Post Translational Modifications Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating.
Function Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH.acidic pH shifts the activation to more negative voltages.
Protein Name Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
Brain Cyclic Nucleotide-Gated Channel 2
Bcng-2
Database Links Reactome: R-HSA-1296061
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibody
Anti-Brain Cyclic Nucleotide-Gated Channel 2 antibody
Anti-Bcng-2 antibody
Anti-HCN2 antibody
Anti-BCNG2 antibody

Information sourced from Uniprot.org

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