Anti-HCN1 antibody (400-450 aa) (STJ13101204)
SPECIFICATIONS
ClonalityPolyclonal
HostSheep
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 400-450 of human HCN1 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Sheep polyclonal anti-HCN1 (400-450 aa) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Sheep |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A concentration of 10-50 ยตg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | HCN1 |
| Gene ID | 348980 |
| Uniprot ID | HCN1_HUMAN |
| Immunogen | A synthetic peptide from aa region 400-450 of human HCN1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 400-450 aa |
| Specificity | Specific for HCN1. |
Additional Info
| Function | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability. Participates in cerebellar mechanisms of motor learning. May mediate responses to sour stimuli. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 1Brain Cyclic Nucleotide-Gated Channel 1Bcng-1 |
| Database Links | Reactome: R-HSA-1296061 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 1 antibodyAnti-Brain Cyclic Nucleotide-Gated Channel 1 antibodyAnti-Bcng-1 antibodyAnti-HCN1 antibodyAnti-BCNG1 antibody |
Information sourced from Uniprot.org