| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HCLS1 |
| Gene ID: | 3059 |
| Uniprot ID: | HCLS1_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human HCLS1 (NP_005326.2). |
| Immunogen Sequence: | MWKSVVGHDVSVSVETQGDD WDTDPDFVNDISEKEQRWGA KTIEGSGRTEHINIHQLRNK VSEEHDVLRKKEMESGPKAS HGYGGRFGVERDRMDKSAVG HEYVAEVEKHSSQTDAAKGF GGKYGVERDRADKSAVGFDY KGEVEKHTSQKDYSRGFGGR YGVEKDKWDKAALGYDYKGE TEKHESQRDYAKGFGGQYGI QKDRVDKSAVGFNEMEAPTT AYKKTTPIEAASSGTRGLK |
| Tissue Specificity | Expressed only in tissues and cells of hematopoietic origin. |
| Post Translational Modifications | Phosphorylated by FES. Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. |
| Function | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| Protein Name | Hematopoietic Lineage Cell-Specific ProteinHematopoietic Cell-Specific Lyn Substrate 1Lckbp1P75 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Hematopoietic Lineage Cell-Specific Protein antibodyAnti-Hematopoietic Cell-Specific Lyn Substrate 1 antibodyAnti-Lckbp1 antibodyAnti-P75 antibodyAnti-HCLS1 antibodyAnti-HS1 antibody |
Information sourced from Uniprot.org