| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DHTKD1 (1-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHTKD1 |
| Gene ID: |
55526 |
| Uniprot ID: |
DHTK1_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DHTKD1 (NP_061176.3). |
| Immunogen Sequence: |
MASATAAAARRGLGRALPLL WRGYQTERGVYGYRPRKPES REPQGALERPPVDHGLARLV TVYCEHGHKAAKINPLFTGQ ALLENVPEIQALVQTLQGPF HTAGLLNMGKEEASLEEVLV YLNQIYCGQISIETSQLQSQ DEKDWFAKRFEELQKETFTT EERKHLSKLMLESQEFDHFL ATKFSTVKRYGGEGAESMMG FFHELLKMSAYSGITDVIIG MPHRGRLNLLTGLLQFPPE |
| Function | 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable). |
| Protein Name | 2-Oxoadipate Dehydrogenase Complex Component E1E1aOadc-E1Oadh-E12-Oxoadipate Dehydrogenase - MitochondrialAlpha-Ketoadipate DehydrogenaseAlpha-Kadh-E1Dehydrogenase E1 And Transketolase Domain-Containing Protein 1Probable 2-Oxoglutarate Dehydrogenase E1 Component Dhktd1 - Mitochondrial |
| Database Links | Reactome: R-HSA-389661 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-2-Oxoadipate Dehydrogenase Complex Component E1 antibodyAnti-E1a antibodyAnti-Oadc-E1 antibodyAnti-Oadh-E1 antibodyAnti-2-Oxoadipate Dehydrogenase - Mitochondrial antibodyAnti-Alpha-Ketoadipate Dehydrogenase antibodyAnti-Alpha-Kadh-E1 antibodyAnti-Dehydrogenase E1 And Transketolase Domain-Containing Protein 1 antibodyAnti-Probable 2-Oxoglutarate Dehydrogenase E1 Component Dhktd1 - Mitochondrial antibodyAnti-DHTKD1 antibodyAnti-KIAA1630 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
