Anti-HCAM antibody [DF 1485] (STJ16100826)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenCD44 antigen (PGp-1) purified from lymphocyte membrane
General Information
| Short Description | Mouse monoclonal anti-HCAM for use in IHC-F, IHC-P, FC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/IHC-P/FC/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | DF 1485 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Dilution Range | IHC-FIHC-P 1:5-1:10FCWB |
| Formulation | Contains 0.09% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | CD44 antigen (PGp-1) purified from lymphocyte membrane |
Additional Info
| Background | CD44 (HCAM) is a transmembrane protein expressed by lymphocytes, erythrocytes and several normal epithelial cells and is a member of the CAM family. It is involved in lymphocyte homing, T-lymphocyte activation, interaction with hyaluronic acid and may act as an adhesion molecule. The human CD44 is composed of 19 exons, 9 variably expressed due to alternative splicing of mRNA; RT CD44 (CD44s) is composed of exons 1-5 and 15-19. The loss of CD44s expression predicts unfavorable outcome in bladder cancers, squamous cell carcinomas of the skin, prostatic adenocarcinoma and neuroblastomas. In immunoblotting the antibody reacts with a glycoprotein isolated from hematopoetic cells and epithelial cells with a respective molecular weight of 29-37 kD and 51 kD. Positive control: Tonsil (cell membrane staining). |
Information sourced from Uniprot.org