Anti-HBS1L antibody (STJA0007210)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HBS1L
General Information
| Short Description | Rabbit polyclonal anti-HBS1-like protein for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HBS1L |
| Gene ID | 10767 |
| Uniprot ID | HBS1L_HUMAN |
| Immunogen | Synthesized peptide derived from human HBS1L |
| Specificity | This antibody detects endogenous levels of HBS1L at Human, Mouse, Rat |
Additional Info
| Function | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. |
| Protein Name | Hbs1-Like ProteinErfs |
| Database Links | Reactome: R-HSA-429958 |
| Cellular Localisation | CytoplasmIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Hbs1-Like Protein antibodyAnti-Erfs antibodyAnti-HBS1L antibodyAnti-HBS1 antibodyAnti-KIAA1038 antibody |
Information sourced from Uniprot.org