Anti-HAX1 antibody (STJA0006936)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HAX1
General Information
| Short Description | Rabbit polyclonal anti-HCLS1-associated protein X-1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAX1 |
| Gene ID | 10456 |
| Uniprot ID | HAX1_HUMAN |
| Immunogen | Synthesized peptide derived from human HAX1 |
| Specificity | This antibody detects endogenous levels of HAX1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
| Protein Name | Hcls1-Associated Protein X-1Hs1-Associating Protein X-1Hax-1Hs1-Binding Protein 1Hsp1bp-1 |
| Database Links | |
| Cellular Localisation | Mitochondrion MatrixEndoplasmic ReticulumNucleus MembraneCytoplasmic VesicleCytoplasmCell CortexCell MembranePeripheral Membrane ProteinCytoplasmic SideSarcoplasmic ReticulumP-BodyIsoform 1: CytoplasmNucleusPredominantly CytoplasmicAlso Detected In The Nucleus When Nuclear Export Is InhibitedAnd In Response To Cellular Stress Caused By Arsenite (In Vitro)Isoform 3: CytoplasmAlso Detected In The Nucleus When Nuclear Export Is Inhibited (In Vitro)Isoform 4: CytoplasmShuttles Between Nucleus And CytoplasmIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Hcls1-Associated Protein X-1 antibodyAnti-Hs1-Associating Protein X-1 antibodyAnti-Hax-1 antibodyAnti-Hs1-Binding Protein 1 antibodyAnti-Hsp1bp-1 antibodyAnti-HAX1 antibodyAnti-HS1BP1 antibody |
Information sourced from Uniprot.org