Anti-HAX1 antibody (Internal) (STJ71829)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-HAX1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 33kDa band observed in Human Kidney, Liver and Testis lysates (calculated MW of 31.6kDa according to NP_006109.2). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | HAX1 |
| Gene ID | 10456 |
| Uniprot ID | HAX1_HUMAN |
| Accession Number | NP_006109.2; NP_001018238.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TRHEADSSPRGDPES |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_006109.2 and NP_001018238.1). |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
| Protein Name | Hcls1-Associated Protein X-1Hs1-Associating Protein X-1Hax-1Hs1-Binding Protein 1Hsp1bp-1 |
| Cellular Localisation | Mitochondrion MatrixEndoplasmic ReticulumNucleus MembraneCytoplasmic VesicleCytoplasmCell CortexCell MembranePeripheral Membrane ProteinCytoplasmic SideSarcoplasmic ReticulumP-BodyIsoform 1: CytoplasmNucleusPredominantly CytoplasmicAlso Detected In The Nucleus When Nuclear Export Is InhibitedAnd In Response To Cellular Stress Caused By Arsenite (In Vitro)Isoform 3: CytoplasmAlso Detected In The Nucleus When Nuclear Export Is Inhibited (In Vitro)Isoform 4: CytoplasmShuttles Between Nucleus And CytoplasmIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Hcls1-Associated Protein X-1 antibodyAnti-Hs1-Associating Protein X-1 antibodyAnti-Hax-1 antibodyAnti-Hs1-Binding Protein 1 antibodyAnti-Hsp1bp-1 antibodyAnti-HAX1 antibodyAnti-HS1BP1 antibody |
Information sourced from Uniprot.org