| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HAS3 (67-281) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HAS3 |
| Gene ID: |
3038 |
| Uniprot ID: |
HYAS3_HUMAN |
| Immunogen Region: |
67-281 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 67-281 of human HAS3 (NP_619515.1). |
| Immunogen Sequence: |
HRRMRRAGQALKLPSPRRGS VALCIAAYQEDPDYLRKCLR SAQRISFPDLKVVMVVDGNR QEDAYMLDIFHEVLGGTEQA GFFVWRSNFHEAGEGETEAS LQEGMDRVRDVVRASTFSCI MQKWGGKREVMYTAFKALGD SVDYIQVCDSDTVLDPACTI EMLRVLEEDPQVGGVGGDVQ PPGKGMAVEDDQVQAAQVRA TEAWSVHQRHVSREQ |
| Post Translational Modifications | O-GlcNAcylation increases the hyaluronan synthase activity, HAS3 stability and its plasma membrane residence. The concentration of UDP-GlcNAc controls the level of O-GlcNAc modification. |
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. |
| Protein Name | Hyaluronan Synthase 3Hyaluronate Synthase 3Hyaluronic Acid Synthase 3Ha Synthase 3 |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneGolgi ApparatusTrans-Golgi Network MembraneEarly EndosomeTravels From Endoplasmic Reticulum (Er)Golgi To Plasma MembraneActives Only When Present In Plasma MembraneO-Glcnacylation Controls Its Membrane LocalizationA Rapid Recycling Of Has3 Between Plasma Membrane And Endosomes Is Controlled By The Cytosolic Levels Of Udp-Glcua And Udp-Glcnac |
| Alternative Antibody Names | Anti-Hyaluronan Synthase 3 antibodyAnti-Hyaluronate Synthase 3 antibodyAnti-Hyaluronic Acid Synthase 3 antibodyAnti-Ha Synthase 3 antibodyAnti-HAS3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
