| Short Description : | Mouse monoclonal anti-Haptoglobin for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | ZN10 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Concentration: | 0.5-1.0 mg/mL |
| Purification: | Affinity Chromatography |
| Dilution Range: | IHC 1:50-1:100 |
| Formulation: | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | HP |
| Gene ID: | 3240 |
| Uniprot ID: | HPT_HUMAN |
| Immunogen: | Full length human recombinant protein of human HP (NP_005134) produced in HEK293T cell. |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Function | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. |
| Protein Name | HaptoglobinZonulin Cleaved Into - Haptoglobin Alpha Chain - Haptoglobin Beta Chain |
| Database Links | Reactome: R-HSA-2168880Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Haptoglobin antibodyAnti-Zonulin Cleaved Into - Haptoglobin Alpha Chain - Haptoglobin Beta Chain antibodyAnti-HP antibody |
Information sourced from Uniprot.org
