Anti-HAND2 antibody (151-217) (STJ29124)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HAND2 (151-217) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAND2 |
| Gene ID | 9464 |
| Uniprot ID | HAND2_HUMAN |
| Immunogen Region | 151-217 |
| Immunogen Sequence | LMDLLAKDDQNGEAEAFKAE IKKTDVKEEKRKKELNEILK STVSSNDKKTKGRTGWPQHV WALELKQ |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 151-217 of human HAND2 (NP_068808.1). |
Additional Info
| Tissue Specificity | Heart. |
| Function | Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. |
| Protein Name | Heart- And Neural Crest Derivatives-Expressed Protein 2Class A Basic Helix-Loop-Helix Protein 26Bhlha26Deciduum - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 2Dhand |
| Database Links | Reactome: R-HSA-8878166Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Heart- And Neural Crest Derivatives-Expressed Protein 2 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 26 antibodyAnti-Bhlha26 antibodyAnti-Deciduum - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 2 antibodyAnti-Dhand antibodyAnti-HAND2 antibodyAnti-BHLHA26 antibodyAnti-DHAND antibody |
Information sourced from Uniprot.org