Anti-HAMP antibody (N-Term) (STJ71808)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-HAMP (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments gave an approx 28kDa band in Human Liver lysates after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature fo |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | HAMP |
| Gene ID | 57817 |
| Uniprot ID | HEPC_HUMAN |
| Accession Number | NP_066998.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | TSGSVFPQQTGQLAE |
Additional Info
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa. |
| Protein Name | HepcidinLiver-Expressed Antimicrobial Peptide 1Leap-1Putative Liver Tumor RegressorPltr Cleaved Into - Hepcidin-25Hepc25 - Hepcidin-20Hepc20 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Hepcidin antibodyAnti-Liver-Expressed Antimicrobial Peptide 1 antibodyAnti-Leap-1 antibodyAnti-Putative Liver Tumor Regressor antibodyAnti-Pltr Cleaved Into - Hepcidin-25 antibodyAnti-Hepc25 - Hepcidin-20 antibodyAnti-Hepc20 antibodyAnti-HAMP antibodyAnti-HEPC antibodyAnti-LEAP1 antibodyAnti-UNQ487 antibodyAnti-PRO1003 antibody |
Information sourced from Uniprot.org