| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HADHB (34-270) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HADHB |
| Gene ID: |
3032 |
| Uniprot ID: |
ECHB_HUMAN |
| Immunogen Region: |
34-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 34-270 of human HADHB (NP_000174.1). |
| Immunogen Sequence: |
AAPAVQTKTKKTLAKPNIRN VVVVDGVRTPFLLSGTSYKD LMPHDLARAALTGLLHRTSV PKEVVDYIIFGTVIQEVKTS NVAREAALGAGFSDKTPAHT VTMACISANQAMTTGVGLIA SGQCDVIVAGGVELMSDVPI RHSRKMRKLMLDLNKAKSMG QRLSLISKFRFNFLAPELPA VSEFSTSETMGHSADRLAAA FAVSRLEQDEYALRSHSLAK KAQDEGLLSDVVPFKVP |
| Function | Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity. |
| Protein Name | Trifunctional Enzyme Subunit Beta - MitochondrialTp-Beta Includes - 3-Ketoacyl-Coa ThiolaseAcetyl-Coa AcyltransferaseBeta-Ketothiolase |
| Database Links | Reactome: R-HSA-1482798Reactome: R-HSA-77285Reactome: R-HSA-77288Reactome: R-HSA-77305Reactome: R-HSA-77310Reactome: R-HSA-77346Reactome: R-HSA-77348Reactome: R-HSA-77350 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembraneMitochondrion Outer MembraneEndoplasmic ReticulumProtein Stability And Association With Membranes Require Hadha |
| Alternative Antibody Names | Anti-Trifunctional Enzyme Subunit Beta - Mitochondrial antibodyAnti-Tp-Beta Includes - 3-Ketoacyl-Coa Thiolase antibodyAnti-Acetyl-Coa Acyltransferase antibodyAnti-Beta-Ketothiolase antibodyAnti-HADHB antibodyAnti-MSTP029 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
