Anti-H6PD antibody (STJA0007813)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human H6PD
General Information
| Short Description | Rabbit polyclonal anti-GDH/6PGL endoplasmic bifunctional protein for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | H6PD |
| Gene ID | 9563 |
| Uniprot ID | G6PE_HUMAN |
| Immunogen | Synthesized peptide derived from human H6PD |
| Specificity | This antibody detects endogenous levels of H6PD at Human, Mouse |
Additional Info
| Function | Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity. |
| Protein Name | Gdh/6pgl Endoplasmic Bifunctional Protein Includes - Hexose-6-Phosphate DehydrogenaseGlucose 1-DehydrogenaseGdhGlucose-6-Phosphate Dehydrogenase - 6-Phosphogluconolactonase6pgl |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Gdh/6pgl Endoplasmic Bifunctional Protein Includes - Hexose-6-Phosphate Dehydrogenase antibodyAnti-Glucose 1-Dehydrogenase antibodyAnti-Gdh antibodyAnti-Glucose-6-Phosphate Dehydrogenase - 6-Phosphogluconolactonase antibodyAnti-6pgl antibodyAnti-H6PD antibodyAnti-GDH antibody |
Information sourced from Uniprot.org