Anti-GZMB antibody (1-50) {Biotin} (STJ501291)

SKU:
STJ501291-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Monkey/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GZMB (1-50) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.52 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GZMB
Gene ID: 3002
Uniprot ID: GRAB_HUMAN
Immunogen Region: 1-50
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human endogenous Granzyme B protein.
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Protein Name Granzyme B
C11
Ctla-1
Cathepsin G-Like 1
Ctsgl1
Cytotoxic T-Lymphocyte Proteinase 2
Lymphocyte Protease
Fragmentin-2
Granzyme-2
Human Lymphocyte Protein
Hlp
Sect
T-Cell Serine Protease 1-3e
Database Links Reactome: R-HSA-2197563
Reactome: R-HSA-5620971
Reactome: R-HSA-75108
Cellular Localisation Secreted
Cytolytic Granule
Delivered Into The Target Cell By Perforin
Alternative Antibody Names Anti-Granzyme B antibody
Anti-C11 antibody
Anti-Ctla-1 antibody
Anti-Cathepsin G-Like 1 antibody
Anti-Ctsgl1 antibody
Anti-Cytotoxic T-Lymphocyte Proteinase 2 antibody
Anti-Lymphocyte Protease antibody
Anti-Fragmentin-2 antibody
Anti-Granzyme-2 antibody
Anti-Human Lymphocyte Protein antibody
Anti-Hlp antibody
Anti-Sect antibody
Anti-T-Cell Serine Protease 1-3e antibody
Anti-GZMB antibody
Anti-CGL1 antibody
Anti-CSPB antibody
Anti-CTLA1 antibody
Anti-GRB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance