Anti-GZMA antibody [SRM15026] (STJ11109756)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal GZMA antibody for use in WB, IP, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM15026 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:10000-1:40000IP, 0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsIF/ICC, 1:100-1:400ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requ |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GZMA |
| Gene ID | 3001 |
| Uniprot ID | GRAA_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
| Protein Name | Granzyme ACtl TryptaseCytotoxic T-Lymphocyte Proteinase 1Fragmentin-1Granzyme-1Hanukkah FactorH FactorHf |
| Database Links | |
| Cellular Localisation | Isoform Alpha: SecretedCytoplasmic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Antibody Names | Anti-Granzyme A antibodyAnti-Ctl Tryptase antibodyAnti-Cytotoxic T-Lymphocyte Proteinase 1 antibodyAnti-Fragmentin-1 antibodyAnti-Granzyme-1 antibodyAnti-Hanukkah Factor antibodyAnti-H Factor antibodyAnti-Hf antibodyAnti-GZMA antibodyAnti-CTLA3 antibodyAnti-HFSP antibody |
Information sourced from Uniprot.org