| Post Translational Modifications | The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-NeuAc-alpha-(2-6)-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-NeuAc-alpha-(2-6)-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-Fuc-alpha-(1-2)-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-Fuc-alpha-(1-2)-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific). |
| Function | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175).binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. |
| Protein Name | Glycophorin-AMn SialoglycoproteinPas-2Sialoglycoprotein AlphaCd Antigen Cd235a |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinAppears To Be Colocalized With Slc4a1 |
| Alternative Antibody Names | Anti-Glycophorin-A antibodyAnti-Mn Sialoglycoprotein antibodyAnti-Pas-2 antibodyAnti-Sialoglycoprotein Alpha antibodyAnti-Cd Antigen Cd235a antibodyAnti-GYPA antibodyAnti-GPA antibodyAnti-MNS antibody |
Information sourced from Uniprot.org
