Anti-GUK1 antibody (STJA0008565)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GUK1
General Information
| Short Description | Rabbit polyclonal anti-Guanylate kinase for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GUK1 |
| Gene ID | 2987 |
| Uniprot ID | KGUA_HUMAN |
| Immunogen | Synthesized peptide derived from human GUK1 |
| Specificity | This antibody detects endogenous levels of GUK1 at Human |
Additional Info
| Function | Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine. |
| Protein Name | Guanylate KinaseGmp KinaseGuanylate Kinase 1 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-9748787 |
| Cellular Localisation | Photoreceptor Inner SegmentCytoplasmCytosolColocalizes With Rd3 In Photoreceptor Inner Segments And To A Lesser Extent In The Outer Plexiform LayerIsoform 2: Mitochondrion |
| Alternative Antibody Names | Anti-Guanylate Kinase antibodyAnti-Gmp Kinase antibodyAnti-Guanylate Kinase 1 antibodyAnti-GUK1 antibodyAnti-GMK antibodyAnti-GMPK antibody |
Information sourced from Uniprot.org