| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Guanylyl cyclase C is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GUCY2C |
| Gene ID: |
2984 |
| Uniprot ID: |
GUC2C_HUMAN |
| Specificity: |
This antibody detects endogenous levels of GUCY2C at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human GUCY2C |
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. |
| Protein Name | Guanylyl Cyclase CGc-CHeat-Stable Enterotoxin ReceptorSta ReceptorHstarIntestinal Guanylate Cyclase |
| Database Links | Reactome: R-HSA-8935690Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneThe 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose ResiduesWhile A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form |
| Alternative Antibody Names | Anti-Guanylyl Cyclase C antibodyAnti-Gc-C antibodyAnti-Heat-Stable Enterotoxin Receptor antibodyAnti-Sta Receptor antibodyAnti-Hstar antibodyAnti-Intestinal Guanylate Cyclase antibodyAnti-GUCY2C antibodyAnti-GUC2C antibodyAnti-STAR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
