Anti-GUCY2C antibody (STJA0009751)

SKU:
STJA0009751
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Guanylyl cyclase C is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GUCY2C
Gene ID: 2984
Uniprot ID: GUC2C_HUMAN
Specificity: This antibody detects endogenous levels of GUCY2C at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human GUCY2C
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin.
Protein Name Guanylyl Cyclase C
Gc-C
Heat-Stable Enterotoxin Receptor
Sta Receptor
Hstar
Intestinal Guanylate Cyclase
Database Links Reactome: R-HSA-8935690
Reactome: R-HSA-8942233
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
The 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose Residues
While A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form
Alternative Antibody Names Anti-Guanylyl Cyclase C antibody
Anti-Gc-C antibody
Anti-Heat-Stable Enterotoxin Receptor antibody
Anti-Sta Receptor antibody
Anti-Hstar antibody
Anti-Intestinal Guanylate Cyclase antibody
Anti-GUCY2C antibody
Anti-GUC2C antibody
Anti-STAR antibody

Information sourced from Uniprot.org

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