Anti-GUCY2C antibody [SAA0124] (STJA0027023)

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STJA0027023-100
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Short Description :Human monoclonal Guanylyl Cyclase C antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC
Host:Human
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA0124
Isotype:IgG1k
Conjugation:Unconjugated
Concentration:2.32 mg/ml
Purification:Protein A/G purified from cell culture supernatant.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:GUCY2C
Gene ID:2984
Uniprot ID:GUC2C_HUMAN
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin.
Protein Name Guanylyl Cyclase C
Gc-C
Heat-Stable Enterotoxin Receptor
Sta Receptor
Hstar
Intestinal Guanylate Cyclase
Database Links Reactome: R-HSA-8935690
Reactome: R-HSA-8942233
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
The 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose Residues
While A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form
Alternative Antibody Names Anti-Guanylyl Cyclase C antibody
Anti-Gc-C antibody
Anti-Heat-Stable Enterotoxin Receptor antibody
Anti-Sta Receptor antibody
Anti-Hstar antibody
Anti-Intestinal Guanylate Cyclase antibody
Anti-GUCY2C antibody
Anti-GUC2C antibody
Anti-STAR antibody

Information sourced from Uniprot.org

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