Anti-GUCY2C antibody (24-330) (STJ112579)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GUCY2C (24-330) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GUCY2C |
| Gene ID | 2984 |
| Uniprot ID | GUC2C_HUMAN |
| Immunogen Region | 24-330 |
| Immunogen Sequence | SQVSQNCHNGSYEISVLMMG NSAFAEPLKNLEDAVNEGLE IVRGRLQNAGLNVTVNATFM YSDGLIHNSGDCRSSTCEGL DLLRKISNAQRMGCVLIGPS CTYSTFQMYLDTELSYPMIS AGSFGLSCDYKETLTRLMSP ARKLMYFLVNFWKTNDLPFK TYSWSTSYVYKNGTETEDCF WYLNALEASVSYFSHELGFK VVLRQDKEFQDILMDHNRKS NVIIMCGGPEFLYKLKGDR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-330 of human GUCY2C (NP_004954.2). |
Additional Info
| Post Translational Modifications | Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GUCY2C activation. |
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. |
| Protein Name | Guanylyl Cyclase CGc-CHeat-Stable Enterotoxin ReceptorSta ReceptorHstarIntestinal Guanylate Cyclase |
| Database Links | Reactome: R-HSA-8935690Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneThe 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose ResiduesWhile A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form |
| Alternative Antibody Names | Anti-Guanylyl Cyclase C antibodyAnti-Gc-C antibodyAnti-Heat-Stable Enterotoxin Receptor antibodyAnti-Sta Receptor antibodyAnti-Hstar antibodyAnti-Intestinal Guanylate Cyclase antibodyAnti-GUCY2C antibodyAnti-GUC2C antibodyAnti-STAR antibody |
Information sourced from Uniprot.org