| Host: | Rabbit |
| Applications: | WB/IP |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-GTF2H3 (1-308) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IP 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GTF2H3 |
| Gene ID: | 2967 |
| Uniprot ID: | TF2H3_HUMAN |
| Immunogen Region: | 1-308 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-308 of human GTF2H3 (NP_001507.2). |
| Immunogen Sequence: | MVSDEDELNLLVIVVDANPI WWGKQALKESQFTLSKCIDA VMVLGNSHLFMNRSNKLAVI ASHIQESRFLYPGKNGRLGD FFGDPGNPPEFNPSGSKDGK YELLTSANEVIVEEIKDLMT KSDIKGQHTETLLAGSLAKA LCYIHRMNKEVKDNQEMKSR ILVIKAAEDSALQYMNFMNV IFAAQKQNILIDACVLDSDS GLLQQACDITGGLYLKVPQM PSLLQYLLWVFLPDQDQRS |
| Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
| Protein Name | General Transcription Factor Iih Subunit 3Basic Transcription Factor 2 34 Kda SubunitBtf2 P34General Transcription Factor Iih Polypeptide 3Tfiih Basal Transcription Factor Complex P34 Subunit |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167246Reactome: R-HSA-427413Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-72086Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73863Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-77075 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-General Transcription Factor Iih Subunit 3 antibodyAnti-Basic Transcription Factor 2 34 Kda Subunit antibodyAnti-Btf2 P34 antibodyAnti-General Transcription Factor Iih Polypeptide 3 antibodyAnti-Tfiih Basal Transcription Factor Complex P34 Subunit antibodyAnti-GTF2H3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
