Anti-GSPT2 antibody (STJA0004584)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human GSPT2
General Information
| Short Description | Rabbit polyclonal antibody anti-Eukaryotic Peptide Chain Release Factor Gtp-Binding Subunit Erf3b is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.84 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | WB 1:500-1:2000, IHC 1:30-1:150 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | GSPT2 |
| Gene ID | 23708 |
| Uniprot ID | ERF3B_HUMAN |
| Immunogen | Fusion protein of human GSPT2 |
Additional Info
| Tissue Specificity | Highly expressed in IUCC stage II colorectal cancer (CRC). |
| Function | GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. |
| Protein Name | Eukaryotic Peptide Chain Release Factor Gtp-Binding Subunit Erf3bEukaryotic Peptide Chain Release Factor Subunit 3bErf3bG1 To S Phase Transition Protein 2 Homolog |
| Database Links | Reactome: R-HSA-72764Reactome: R-HSA-9010553Reactome: R-HSA-975956Reactome: R-HSA-975957 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Eukaryotic Peptide Chain Release Factor Gtp-Binding Subunit Erf3b antibodyAnti-Eukaryotic Peptide Chain Release Factor Subunit 3b antibodyAnti-Erf3b antibodyAnti-G1 To S Phase Transition Protein 2 Homolog antibodyAnti-GSPT2 antibodyAnti-ERF3B antibody |
Information sourced from Uniprot.org