![Anti-GRM2 nanobody [SAA1127] (STJN000270)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200883/413065/STJN000270-SDS-PAGE-1__52474.1749232573.jpg?c=1 "Anti-GRM2 nanobody [SAA1127] (STJN000270)")
![Anti-GRM2 nanobody [SAA1127] (STJN000270)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200883/413065/STJN000270-SDS-PAGE-1__52474.1749232573.jpg?c=1 "Anti-GRM2 nanobody [SAA1127] (STJN000270)")
Anti-GRM2 nanobody [SAA1127] (STJN000270)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Metabotropic Glutamate Receptor 2 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1127 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | GRM2 |
| Gene ID | 2912 |
| Uniprot ID | GRM2_HUMAN |
Additional Info
| Function | Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. (Microbial infection) Plays an important role in influenza virus internalization. (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells. (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells. |
| Protein Name | Metabotropic Glutamate Receptor 2Mglur2 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSynapseCell ProjectionDendrite |
| Alternative Nanobody Names | Anti-Metabotropic Glutamate Receptor 2 nanobodyAnti-Mglur2 nanobodyAnti-GRM2 nanobodyAnti-GPRC1B nanobodyAnti-MGLUR2 nanobody |
Information sourced from Uniprot.org