| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-GRK6 (97-110 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
R07-3E4 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: |
Affinity Purified |
| Concentration: |
0.3 mg/ml |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: |
GRK6 |
| Gene ID: |
2870 |
| Uniprot ID: |
GRK6_HUMAN |
| Immunogen Region: |
97-110 aa |
| Immunogen: |
A synthetic peptide of human GRK6 |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. |
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| Protein Name | G Protein-Coupled Receptor Kinase 6G Protein-Coupled Receptor Kinase Grk6 |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-G Protein-Coupled Receptor Kinase 6 antibodyAnti-G Protein-Coupled Receptor Kinase Grk6 antibodyAnti-GRK6 antibodyAnti-GPRK6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
