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Anti-GRK6 antibody (500-550) (STJ501286)

Western blot with Anti-GRK6 Antibody (STJ501286) on HeLa cell extract at 1:500 dilution in buffer.

Anti-GRK6 antibody (500-550) (STJ501286)

SKU:

STJ501286-100

£441.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	ELISA/IHC/IP/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-GRK6 (500-550) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	GRK6
Gene ID:	2870
Uniprot ID:	GRK6_HUMAN
Immunogen Region:	500-550
Immunogen:	Synthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein.

Tissue Specificity	Widely expressed.
Post Translational Modifications	It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Protein Name	G Protein-Coupled Receptor Kinase 6 G Protein-Coupled Receptor Kinase Grk6
Database Links	Reactome: R-HSA-418555
Cellular Localisation	Membrane Lipid-Anchor
Alternative Antibody Names	Anti-G Protein-Coupled Receptor Kinase 6 antibody Anti-G Protein-Coupled Receptor Kinase Grk6 antibody Anti-GRK6 antibody Anti-GPRK6 antibody

Information sourced from Uniprot.org

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