Anti-GRK6 antibody (500-550) {Biotin} (STJ501287)

Name: Anti-GRK6 antibody (500-550) {Biotin} (STJ501287)
SKU: STJ501287-100
Price: 597 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationBiotin

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein.

STJ501287-100

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Short Description	Rabbit polyclonal antibody anti-GRK6 (500-550) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Biotin
Concentration	0.5-1.5 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:200
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	GRK6
Gene ID	2870
Uniprot ID	GRK6_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein.
Immunogen Region	500-550

Tissue Specificity	Widely expressed.
Post Translational Modifications	It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Protein Name	G Protein-Coupled Receptor Kinase 6 G Protein-Coupled Receptor Kinase Grk6
Database Links	Reactome: R-HSA-418555
Cellular Localisation	Membrane Lipid-Anchor
Alternative Antibody Names	Anti-G Protein-Coupled Receptor Kinase 6 antibody Anti-G Protein-Coupled Receptor Kinase Grk6 antibody Anti-GRK6 antibody Anti-GPRK6 antibody

Information sourced from Uniprot.org