![Anti-GRIN1/NMDAR1 antibody [A4B2/Glunomab] (STJA0019222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/187938/412594/STJA0019222-WB-1__63712.1749229210.jpg?c=1 "Anti-GRIN1/NMDAR1 antibody [A4B2/Glunomab] (STJA0019222)")
![Anti-GRIN1/NMDAR1 antibody [A4B2/Glunomab] (STJA0019222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/187938/412594/STJA0019222-WB-1__63712.1749229210.jpg?c=1 "Anti-GRIN1/NMDAR1 antibody [A4B2/Glunomab] (STJA0019222)")
Anti-GRIN1/NMDAR1 antibody [A4B2/Glunomab] (STJA0019222)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Glutamate Receptor Ionotropic-Nmda 1 antibody for use in Blocking, ELISA and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | Blocking/ELISA/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | A4B2/Glunomab |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | GRIN1 |
| Gene ID | 2902 |
| Uniprot ID | NMDZ1_HUMAN |
Additional Info
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 1Glun1Glutamate Nmda Receptor Subunit Zeta-1N-Methyl-D-Aspartate Receptor Subunit Nr1Nmd-R1Hnr1 |
| Database Links | Reactome: R-HSA-3928662Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density MembraneSynaptic Cell MembraneSynaptic Cell Membrane Targeting Is Dependent Of Grin2b/Glun2b SubunitAssociation With Grin3a Occurs In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 1 antibodyAnti-Glun1 antibodyAnti-Glutamate Nmda Receptor Subunit Zeta-1 antibodyAnti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibodyAnti-Nmd-R1 antibodyAnti-Hnr1 antibodyAnti-GRIN1 antibodyAnti-NMDAR1 antibody |
Information sourced from Uniprot.org