Anti-GRIA3 antibody (200-490 aa) (STJ11106041)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GRIA3 (200-490 aa) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRIA3 |
| Gene ID | 2892 |
| Uniprot ID | GRIA3_HUMAN |
| Immunogen Region | 200-490 aa |
| Immunogen Sequence | QEFRRIIEEMDRRQEKRYLI DCEVERINTILEQVVILGKH SRGYHYMLANLGFTDILLER VMHGGANITGFQIVNNENPM VQQFIQRWVRLDEREFPEAK NAPLKYTSALTHDAILVIAE AFRYLRRQRVDVSRRGSAGD CLANPAVPWSQGIDIERALK MVQVQGMTGNIQFDTYGRRT NYTIDVYEMKVSGSRKAGYW NEYERFVPFSDQQISNDSAS SENRTIVVTTILESPYVMY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 200-490 of human GRIA3 (NP_000819.3). |
Additional Info
| Function | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 3Glur-3Ampa-Selective Glutamate Receptor 3Glur-CGlur-K3Glutamate Receptor Ionotropic - Ampa 3 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor 3 antibodyAnti-Glur-3 antibodyAnti-Ampa-Selective Glutamate Receptor 3 antibodyAnti-Glur-C antibodyAnti-Glur-K3 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 3 antibodyAnti-GRIA3 antibodyAnti-GluA3 antibodyAnti-GLUR3 antibodyAnti-GLURC antibody |
Information sourced from Uniprot.org