• Western blot of a rat hippocampal lysate showing the specific immunolabeling of the ~100 kDa GluR2 protein.

Anti-GRIA2 antibody (STJA0003663)

SKU:
STJA0003663-100

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Host: Rabbit
Applications: WB
Reactivity: Rat/Chicken/Human/Non-Human Primates/Mouse/Zebrafish
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GluR2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gria2
Gene ID: 29627
Uniprot ID: GRIA2_RAT
Immunogen: Synthetic peptide corresponding to amino acid residues specific to GluR2 conjugated to KLH.
Tissue Specificity Detected in forebrain. Detected in dendrites of neuronal cells. Expressed in the pyramidal cell layers of CA1 and CA3 and in the granule cell layer of the dentate gyrus.
Post Translational Modifications Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation. Ubiquitinated by RNF167, leading to its degradation.
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Protein Name Glutamate Receptor 2
Glur-2
Ampa-Selective Glutamate Receptor 2
Glur-B
Glur-K2
Glutamate Receptor Ionotropic - Ampa 2
Glua2
Database Links Reactome: R-RNO-399710
Reactome: -RNO-416993
Reactome: -RNO-438066
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Postsynaptic Density Membrane
Interaction With Cacng2
Cnih2 And Cnih3 Promotes Cell Surface Expression
Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Alternative Antibody Names Anti-Glutamate Receptor 2 antibody
Anti-Glur-2 antibody
Anti-Ampa-Selective Glutamate Receptor 2 antibody
Anti-Glur-B antibody
Anti-Glur-K2 antibody
Anti-Glutamate Receptor Ionotropic - Ampa 2 antibody
Anti-Glua2 antibody
Anti-Gria2 antibody
Anti-Glur2 antibody

Information sourced from Uniprot.org

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