Anti-GRHL1 antibody (STJA0008761)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GRHL1
General Information
| Short Description | Rabbit polyclonal anti-Grainyhead-like protein 1 homolog for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRHL1 |
| Gene ID | 29841 |
| Uniprot ID | GRHL1_HUMAN |
| Immunogen | Synthesized peptide derived from human GRHL1 |
| Specificity | This antibody detects endogenous levels of GRHL1 at Human, Mouse |
Additional Info
| Post Translational Modifications | Methylation at Arg-9 and Lys-116 may be involved in regulating transcriptional activation. |
| Function | Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development. May play a role in regulating glucose homeostasis and insulin signaling. Isoform 1: Functions as a transcription activator. Isoform 2: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. |
| Protein Name | Grainyhead-Like Protein 1 HomologMammalian GrainyheadNh32Transcription Factor Cp2-Like 2Transcription Factor Lbp-32 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Grainyhead-Like Protein 1 Homolog antibodyAnti-Mammalian Grainyhead antibodyAnti-Nh32 antibodyAnti-Transcription Factor Cp2-Like 2 antibodyAnti-Transcription Factor Lbp-32 antibodyAnti-GRHL1 antibodyAnti-LBP32 antibodyAnti-MGR antibodyAnti-TFCP2L2 antibody |
Information sourced from Uniprot.org