Anti-GREM1 antibody (N-Term) (STJA0010313)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human N-ternal GREM1
General Information
| Short Description | Rabbit polyclonal anti-Gremlin-1 (N-Term) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GREM1 |
| Gene ID | 26585 |
| Uniprot ID | GREM1_HUMAN |
| Immunogen | Synthesized peptide derived from human N-ternal GREM1 |
| Immunogen Region | N-Term |
| Specificity | This antibody detects endogenous levels of GREM1 at Human, Mouse, Rat |
Additional Info
| Function | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2.inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. |
| Protein Name | Gremlin-1Cell Proliferation-Inducing Gene 2 ProteinCysteine Knot Superfamily 1 - Bmp Antagonist 1Dan Domain Family Member 2Down-Regulated In Mos-Transformed Cells ProteinIncreased In High Glucose Protein 2Ihg-2 |
| Database Links | Reactome: R-HSA-9830674 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Gremlin-1 antibodyAnti-Cell Proliferation-Inducing Gene 2 Protein antibodyAnti-Cysteine Knot Superfamily 1 - Bmp Antagonist 1 antibodyAnti-Dan Domain Family Member 2 antibodyAnti-Down-Regulated In Mos-Transformed Cells Protein antibodyAnti-Increased In High Glucose Protein 2 antibodyAnti-Ihg-2 antibodyAnti-GREM1 antibodyAnti-CKTSF1B1 antibodyAnti-DAND2 antibodyAnti-DRM antibodyAnti-PIG2 antibody |
Information sourced from Uniprot.org