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Anti-GRB2 antibody (1-217) (STJ27656)

Immunofluorescence analysis of HeLa cells using GRB2 antibody (STJ27656). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using GRB2 antibody (STJ27656) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-GRB2 antibody (1-217) (STJ27656)

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STJ27656

£169.50 - £449.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-GRB2 (1-217) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:10-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	GRB2
Gene ID:	2885
Uniprot ID:	GRB2_HUMAN
Immunogen Region:	1-217
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GRB2 (NP_002077.1).
Immunogen Sequence:	MEAIAKYDFKATADDELSFK RGDILKVLNEECDQNWYKAE LNGKDGFIPKNYIEMKPHPW FFGKIPRAKAEEMLSKQRHD GAFLIRESESAPGDFSLSVK FGNDVQHFKVLRDGAGKYFL WVVKFNSLNELVDYHRSTSV SRNQQIFLRDIEQVPQQPTY VQALFDFDPQEDGELGFRRG DFIHVMDNSDPNWWKGACHG QTGMFPRNYVTPVNRNV

Function	Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Protein Name	Growth Factor Receptor-Bound Protein 2 Adapter Protein Grb2 Protein Ash Sh2/Sh3 Adapter Grb2
Database Links	Reactome: R-HSA-109704 P62993-1 Reactome: R-HSA-112412 P62993-1 Reactome: R-HSA-1236382 P62993-1 Reactome: R-HSA-1250196 P62993-1 Reactome: R-HSA-1250347 P62993-1 Reactome: R-HSA-1257604 P62993-1 Reactome: R-HSA-1295596 P62993-1 Reactome: R-HSA-1433557 P62993-1 Reactome: R-HSA-1433559 P62993-1 Reactome: R-HSA-167044 P62993-1 Reactome: R-HSA-179812 P62993-1 Reactome: R-HSA-180292 P62993-1 Reactome: R-HSA-180336 P62993-1 Reactome: R-HSA-182971 P62993-1 Reactome: R-HSA-1839117 P62993-1 Reactome: R-HSA-186763 P62993-1 Reactome: R-HSA-1963640 P62993-1 Reactome: R-HSA-1963642 P62993-1 Reactome: R-HSA-2029482 P62993-1 Reactome: R-HSA-210993 P62993-1 Reactome: R-HSA-2179392 P62993-1 Reactome: R-HSA-2219530 P62993-1 Reactome: R-HSA-2424491 P62993-1 Reactome: R-HSA-2428933 P62993-1 Reactome: R-HSA-2730905 P62993-1 Reactome: R-HSA-2871796 P62993-1 Reactome: R-HSA-2871809 P62993-1 Reactome: R-HSA-354194 P62993-1 Reactome: R-HSA-375165 P62993-1 Reactome: R-HSA-388841 P62993-1 Reactome: R-HSA-389359 P62993-1 Reactome: R-HSA-391160 P62993-1 Reactome: R-HSA-512988 P62993-1 Reactome: R-HSA-5637810 P62993-1 Reactome: R-HSA-5654688 P62993-1 Reactome: R-HSA-5654689 P62993-1 Reactome: R-HSA-5654693 P62993-1 Reactome: R-HSA-5654695 P62993-1 Reactome: R-HSA-5654699 P62993-1 Reactome: R-HSA-5654700 P62993-1 Reactome: R-HSA-5654704 P62993-1 Reactome: R-HSA-5654706 P62993-1 Reactome: R-HSA-5654710 P62993-1 Reactome: R-HSA-5654712 P62993-1 Reactome: R-HSA-5654719 P62993-1 Reactome: R-HSA-5654720 P62993-1 Reactome: R-HSA-5654726 P62993-1 Reactome: R-HSA-5654727 P62993-1 Reactome: R-HSA-5654732 P62993-1 Reactome: R-HSA-5654733 P62993-1 Reactome: R-HSA-5655253 P62993-1 Reactome: R-HSA-5655291 P62993-1 Reactome: R-HSA-5655302 P62993-1 Reactome: R-HSA-5655332 P62993-1 Reactome: R-HSA-5663213 P62993-1 Reactome: R-HSA-5673001 P62993-1 Reactome: R-HSA-6807004 P62993-1 Reactome: R-HSA-6811558 P62993-1 Reactome: R-HSA-74749 P62993-1 Reactome: R-HSA-74751 P62993-1 Reactome: R-HSA-8851805 P62993-1 Reactome: R-HSA-8851907 P62993-1 Reactome: R-HSA-8853659 P62993-1 Reactome: R-HSA-8856825 P62993-1 Reactome: R-HSA-8856828 P62993-1 Reactome: R-HSA-8865999 P62993-1 Reactome: R-HSA-8875360 P62993-1 Reactome: R-HSA-8875555 P62993-1 Reactome: R-HSA-8875656 P62993-1 Reactome: R-HSA-8983432 Reactome: R-HSA-9013420 P62993-1 Reactome: R-HSA-9026519 P62993-1 Reactome: R-HSA-9027284 P62993-1 Reactome: R-HSA-9028335 P62993-1 Reactome: R-HSA-9028731 P62993-1 Reactome: R-HSA-9034864 P62993-1 Reactome: R-HSA-912526 P62993-1 Reactome: R-HSA-912631 P62993-1 Reactome: R-HSA-9607240 P62993-1 Reactome: R-HSA-9634285 P62993-1 Reactome: R-HSA-9645135 P62993-1 Reactome: R-HSA-9664422 P62993-1 Reactome: R-HSA-9664565 P62993-1 Reactome: R-HSA-9665348 P62993-1 Reactome: R-HSA-9665686 P62993-1 Reactome: R-HSA-9670439 P62993-1 Reactome: R-HSA-9673767 P62993-1 Reactome: R-HSA-9673770 P62993-1 Reactome: R-HSA-9674555 Reactome: R-HSA-9679191 P62993-1 Reactome: R-HSA-9680350 P62993-1 Reactome: R-HSA-9702518 Reactome: R-HSA-9703465 P62993-1 Reactome: R-HSA-9703648 Reactome: R-HSA-9725370 Reactome: R-HSA-983695 P62993-1
Cellular Localisation	Nucleus Cytoplasm Endosome Golgi Apparatus
Alternative Antibody Names	Anti-Growth Factor Receptor-Bound Protein 2 antibody Anti-Adapter Protein Grb2 antibody Anti-Protein Ash antibody Anti-Sh2/Sh3 Adapter Grb2 antibody Anti-GRB2 antibody Anti-ASH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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