Anti-GRASP1/GRIPAP1 antibody (N-Term) (STJ70548)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-GRASP1/GRIPAP1 (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave no signal but low background in Human Brain lysates at up to 1µg/ml.IHC: Paraffin embedded Human Tonsil and Brain (Cortex). Recommended concentration: |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GRIPAP1 |
| Gene ID | 56850 |
| Uniprot ID | GRAP1_HUMAN |
| Accession Number | NP_064522.3; NP_997555.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | LREQTTGLAAELQ |
| Specificity | This antibody is expected to recognize both reported isoforms (as represented by NP_064522.3; NP_997555.1) |
Additional Info
| Function | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. GRASP-1 C-terminal chain: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. |
| Protein Name | Grip1-Associated Protein 1Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain30kda C-Terminus Form |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinRecycling Endosome MembraneCell ProjectionAxonDendriteSynapseLocalizes To Recycling Endosomal Tubules That Are Emanating From Early Endosomes |
| Alternative Antibody Names | Anti-Grip1-Associated Protein 1 antibodyAnti-Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain antibodyAnti-30kda C-Terminus Form antibodyAnti-GRIPAP1 antibodyAnti-KIAA1167 antibody |
Information sourced from Uniprot.org