Anti-Granzyme B antibody [GrB-7] (STJ16100752)

SKU:
STJ16100752-1

Shipping:
Free Shipping
Current Stock:
Host: Mouse
Applications: ICC/ELISA/IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Granzyme B is suitable for use in Immunocytochemistry, ELISA and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: GrB-7
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Serum free tissue culture supernatant with 0.1% BSA and 0.09% sodium azide
Purification: Protein G purified
Concentration: 100 ug/mL
Dilution Range: ICC 1:20
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: GZMB
Gene ID: 3002
Uniprot ID: GRAB_HUMAN
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Protein Name Granzyme B
C11
Ctla-1
Cathepsin G-Like 1
Ctsgl1
Cytotoxic T-Lymphocyte Proteinase 2
Lymphocyte Protease
Fragmentin-2
Granzyme-2
Human Lymphocyte Protein
Hlp
Sect
T-Cell Serine Protease 1-3e
Database Links Reactome: R-HSA-2197563
Reactome: R-HSA-5620971
Reactome: R-HSA-75108
Cellular Localisation Secreted
Cytolytic Granule
Delivered Into The Target Cell By Perforin
Alternative Antibody Names Anti-Granzyme B antibody
Anti-C11 antibody
Anti-Ctla-1 antibody
Anti-Cathepsin G-Like 1 antibody
Anti-Ctsgl1 antibody
Anti-Cytotoxic T-Lymphocyte Proteinase 2 antibody
Anti-Lymphocyte Protease antibody
Anti-Fragmentin-2 antibody
Anti-Granzyme-2 antibody
Anti-Human Lymphocyte Protein antibody
Anti-Hlp antibody
Anti-Sect antibody
Anti-T-Cell Serine Protease 1-3e antibody
Anti-GZMB antibody
Anti-CGL1 antibody
Anti-CSPB antibody
Anti-CTLA1 antibody
Anti-GRB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance