Anti-GRAF antibody [R98-1X-5] (STJA0035576)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human GRAF
General Information
| Short Description | Rabbit monoclonal anti-GRAF for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R98-1X-5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ARHGAP26 |
| Gene ID | 23092 |
| Uniprot ID | RHG26_HUMAN |
| Immunogen | A synthesized peptide derived from human GRAF |
Additional Info
| Post Translational Modifications | Phosphorylated in a PINK1-dependent fashion promoting retrograde mitochondrial trafficking and clustering. |
| Function | GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Isoform 2: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. |
| Protein Name | Rho Gtpase-Activating Protein 26Gtpase Regulator Associated With Focal Adhesion KinaseGraf1Oligophrenin-1-Like ProteinRho-Type Gtpase-Activating Protein 26 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | Isoform 2: Endosome MembraneColocalized With Rab8aRab8b And Rab10 On Endosomal TubulesCytoplasmCell JunctionFocal AdhesionCytoskeletonColocalizes With Actin Stress Fibers And Cortical Actin Structures |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 26 antibodyAnti-Gtpase Regulator Associated With Focal Adhesion Kinase antibodyAnti-Graf1 antibodyAnti-Oligophrenin-1-Like Protein antibodyAnti-Rho-Type Gtpase-Activating Protein 26 antibodyAnti-ARHGAP26 antibodyAnti-GRAF antibodyAnti-KIAA0621 antibodyAnti-OPHN1L antibody |
Information sourced from Uniprot.org