Anti-GPX1 antibody (100-200) (STJ23851)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GPX1 (100-200) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPX1 |
| Gene ID | 2876 |
| Uniprot ID | GPX1_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | RPGGGFEPNFMLFEKCEVNG AGAHPLFAFLREALPAPSDD ATALMTDPKLITWSPVCRND VAWNFEKFLVGPDGVPLRRY SRRFQTIDIEPDIEALLSQG P |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GPX1 (NP_000572.2). |
Additional Info
| Tissue Specificity | Expressed in platelets (at protein level). |
| Post Translational Modifications | During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. |
| Function | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway. |
| Protein Name | Glutathione Peroxidase 1Gpx-1Gshpx-1Cellular Glutathione PeroxidasePhospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142712Reactome: R-HSA-2142770Reactome: R-HSA-3299685 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Glutathione Peroxidase 1 antibodyAnti-Gpx-1 antibodyAnti-Gshpx-1 antibodyAnti-Cellular Glutathione Peroxidase antibodyAnti-Phospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 antibodyAnti-GPX1 antibody |
Information sourced from Uniprot.org