Anti-GPSM2 antibody (STJ190839)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-G-protein-signaling modulator 2 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPSM2 |
| Gene ID | 29899 |
| Uniprot ID | GPSM2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | GPSM2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase. Plays a role in metaphase spindle orientation. Also plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. |
| Protein Name | G-Protein-Signaling Modulator 2Mosaic Protein Lgn |
| Database Links | Reactome: R-HSA-418594 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonSpindle PoleLateral Cell MembraneLocalizes In The Cytoplasm During Interphase And At Cell Cortex During MetaphaseColocalizes With Numa1 To Mitotic Spindle PolesLocalized At The Central And Lateral Cell Cortex Regions In A Rangtp-Dependent MannerIn Horizontally Retinal Progenitor Dividing CellsLocalized To The Lateral Cortical RegionIn Vertically Retinal Progenitor Dividing CellsLocalized At The Polar Cortical Region |
| Alternative Antibody Names | Anti-G-Protein-Signaling Modulator 2 antibodyAnti-Mosaic Protein Lgn antibodyAnti-GPSM2 antibodyAnti-LGN antibody |
Information sourced from Uniprot.org