| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPRC5A (268-357) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPRC5A |
| Gene ID: |
9052 |
| Uniprot ID: |
RAI3_HUMAN |
| Immunogen Region: |
268-357 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 268-357 of human GPRC5A (NP_003970.1). |
| Immunogen Sequence: |
LTKQRNPMDYPVEDAFCKPQ LVKKSYGVENRAYSQEEITQ GFEETGDTLYAPYSTHFQLQ NQPPQKEFSIPRAHAWPSPY KDYEVKKEGS |
| Tissue Specificity | Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal cord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. expressed at low but detectable level in pancreas and heart. |
| Post Translational Modifications | Phosphorylated in two conserved double-tyrosine motifs, Tyr-317/Tyr-320 and Tyr-347/Tyr-350, by EGFR.leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. Tyr-317 and Tyr-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. |
| Function | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. |
| Protein Name | Retinoic Acid-Induced Protein 3G-Protein Coupled Receptor Family C Group 5 Member APhorbol Ester Induced Gene 1Peig-1Retinoic Acid-Induced Gene 1 ProteinRaig-1 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLocalized In Perinuclear VesiclesProbably Golgi-Associated Vesicles |
| Alternative Antibody Names | Anti-Retinoic Acid-Induced Protein 3 antibodyAnti-G-Protein Coupled Receptor Family C Group 5 Member A antibodyAnti-Phorbol Ester Induced Gene 1 antibodyAnti-Peig-1 antibodyAnti-Retinoic Acid-Induced Gene 1 Protein antibodyAnti-Raig-1 antibodyAnti-GPRC5A antibodyAnti-GPCR5A antibodyAnti-RAI3 antibodyAnti-RAIG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
