Anti-GPR75 antibody (490-540) {FITC} (STJ501270)

Name: Anti-GPR75 antibody (490-540) {FITC} (STJ501270)
SKU: STJ501270-100
Price: 497.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationFITC

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid reigon 490-540 on human G protein-coupled receptor 75 protein.

STJ501270-100

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Short Description	Rabbit polyclonal antibody anti-GPR75 (490-540) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunohistochemistry, Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Applications	CM/ELISA/ICC/IHC/IF/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	FITC
Concentration	0.75-1.25 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:250 IHC: 1:250 ICC: 1:250 IF: 1:250 CFM: 1:250
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	GPR75
Gene ID	10936
Uniprot ID	GPR75_HUMAN
Immunogen	Synthetic peptide taken within amino acid reigon 490-540 on human G protein-coupled receptor 75 protein.
Immunogen Region	490-540

Tissue Specificity	Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).
Function	G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Protein Name	Probable G-Protein Coupled Receptor 75
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Probable G-Protein Coupled Receptor 75 antibody Anti-GPR75 antibody

Information sourced from Uniprot.org