Anti-GPR40 antibody (C-Term) (STJ70707)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-GPR40 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 28kDa band observed in Human Breast lysates (calculated MW of 31.5kDa according to NP_005294.1). Recommended concentration: 0.01-0.03µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | FFAR1 |
| Gene ID | 2864 |
| Uniprot ID | FFAR1_HUMAN |
| Accession Number | NP_005294.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | CAARTQGGKSQK |
Additional Info
| Function | G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis.receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. |
| Protein Name | Free Fatty Acid Receptor 1G-Protein Coupled Receptor 40 |
| Database Links | Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-416476Reactome: R-HSA-434316Reactome: R-HSA-444209 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Free Fatty Acid Receptor 1 antibodyAnti-G-Protein Coupled Receptor 40 antibodyAnti-FFAR1 antibodyAnti-GPR40 antibody |
Information sourced from Uniprot.org