Anti-GPR37L1 antibody (1-50 aa) (STJ93382)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ETBR2 at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-G-protein coupled receptor 37-like 1 (1-50 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPR37L1 |
| Gene ID | 9283 |
| Uniprot ID | G37L1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ETBR2 at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | GPR37L1 Polyclonal Antibody detects endogenous levels of GPR37L1 protein. |
Additional Info
| Post Translational Modifications | O-glycosylated. Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity. Ubiquitinated. |
| Function | G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity. |
| Protein Name | G-Protein Coupled Receptor 37-Like 1Endothelin B Receptor-Like Protein 2Etbr-Lp-2 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCilium MembraneAssociates With The Basal Membrane Of Bergmann Glia Cell Primary Cilia |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 37-Like 1 antibodyAnti-Endothelin B Receptor-Like Protein 2 antibodyAnti-Etbr-Lp-2 antibodyAnti-GPR37L1 antibodyAnti-ETBRLP2 antibody |
Information sourced from Uniprot.org