| Post Translational Modifications | O-glycosylated. Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity. Ubiquitinated. |
| Function | G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity. |
| Protein Name | G-Protein Coupled Receptor 37-Like 1Endothelin B Receptor-Like Protein 2Etbr-Lp-2 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCilium MembraneAssociates With The Basal Membrane Of Bergmann Glia Cell Primary Cilia |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 37-Like 1 antibodyAnti-Endothelin B Receptor-Like Protein 2 antibodyAnti-Etbr-Lp-2 antibodyAnti-GPR37L1 antibodyAnti-ETBRLP2 antibody |
Information sourced from Uniprot.org
