Anti-GPR179 antibody (STJ192655)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Probable G-protein coupled receptor 179 for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPR179 |
| Gene ID | 440435 |
| Uniprot ID | GP179_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | GP179 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Orphan receptor involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1. |
| Protein Name | Probable G-Protein Coupled Receptor 179Probable G-Protein Coupled Receptor 158-Like 1Gpr158-Like |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteSpecifically Localizes To The Tips Of Retinal On-Bipolar Dendrites |
| Alternative Antibody Names | Anti-Probable G-Protein Coupled Receptor 179 antibodyAnti-Probable G-Protein Coupled Receptor 158-Like 1 antibodyAnti-Gpr158-Like antibodyAnti-GPR179 antibodyAnti-GPR158L antibodyAnti-GPR158L1 antibody |
Information sourced from Uniprot.org