• Western blot analysis of various lysates using GPR155 Rabbit polyclonal antibody (STJ118613) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-GPR155 antibody (721-870) (STJ118613)

SKU:
STJ118613

$151.88 - $705.38
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GPR155 (721-870) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GPR155
Gene ID: 151556
Uniprot ID: LYCHS_HUMAN
Immunogen Region: 721-870
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 721-870 of human GPR155 (NP_001028217.1).
Immunogen Sequence: PFKRRLEFLWNNKDTAENRD SPVSEEIKMTCQQFIHYHRD LCIRNIVKERRCGAKTSAGT FCGCDLVSWLIEVGLASDRG EAVIYGDRLVQGGVIQHITN EYEFRDEYLFYRFLQKSPEQ SPPAINANTLQQERYKEIEH SSPPSHSPKT
Function Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway. Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition.
Protein Name Lysosomal Cholesterol Signaling Protein
Lychos
G-Protein Coupled Receptor Pgr22
Cellular Localisation Lysosome Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Lysosomal Cholesterol Signaling Protein antibody
Anti-Lychos antibody
Anti-G-Protein Coupled Receptor Pgr22 antibody
Anti-GPR155 antibody
Anti-PGR22 antibody

Information sourced from Uniprot.org

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