Anti-GPR155 antibody (721-870) (STJ118613)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GPR155 (721-870) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPR155 |
| Gene ID | 151556 |
| Uniprot ID | LYCHS_HUMAN |
| Immunogen Region | 721-870 |
| Immunogen Sequence | PFKRRLEFLWNNKDTAENRD SPVSEEIKMTCQQFIHYHRD LCIRNIVKERRCGAKTSAGT FCGCDLVSWLIEVGLASDRG EAVIYGDRLVQGGVIQHITN EYEFRDEYLFYRFLQKSPEQ SPPAINANTLQQERYKEIEH SSPPSHSPKT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 721-870 of human GPR155 (NP_001028217.1). |
Additional Info
| Function | Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway. Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling. Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition. Binds indole-3-acetic acid and may play a role in tryptophan metabolism. |
| Protein Name | Lysosomal Cholesterol Signaling ProteinLychosG-Protein Coupled Receptor Pgr22 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Lysosomal Cholesterol Signaling Protein antibodyAnti-Lychos antibodyAnti-G-Protein Coupled Receptor Pgr22 antibodyAnti-GPR155 antibodyAnti-PGR22 antibody |
Information sourced from Uniprot.org