| Short Description : | Rabbit polyclonal anti-Integral membrane protein GPR137B (320-400 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPR137B |
| Gene ID: | 7107 |
| Uniprot ID: | G137B_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 320-400 |
| Immunogen Region: | 320-400 aa |
| Specificity: | G137B Polyclonal Antibody detects endogenous levels of protein. |
| Function | Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy. Also acts as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polarization. |
| Protein Name | Integral Membrane Protein Gpr137bTransmembrane 7 Superfamily Member 1 Protein |
| Database Links | |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinColocalized With Mtor In Lysosome After Amino Acid Stimulation |
| Alternative Antibody Names | Anti-Integral Membrane Protein Gpr137b antibodyAnti-Transmembrane 7 Superfamily Member 1 Protein antibodyAnti-GPR137B antibodyAnti-TM7SF1 antibody |
Information sourced from Uniprot.org
