| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Gephyrin (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S0MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPHN |
| Gene ID: |
10243 |
| Uniprot ID: |
GEPH_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Gephyrin (NP_001019389). |
| Immunogen Sequence: |
MATEGMILTNHDHQIRVGVL TVSDSCFRNLAEDRSGINLK DLVQDPSLLGGTISAYKIVP DEIEEIKETLIDWCDEKELN LILTTGGTGFAPRDVTPEAT |
| Post Translational Modifications | Palmitoylated. Palmitoylation is stimulated by GABA type A receptors activity. Palmitoylation by ZDHHC12 regulates clustering at synapses. |
| Function | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors. Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
| Protein Name | Gephyrin Includes - Molybdopterin AdenylyltransferaseMpt AdenylyltransferaseDomain G - Molybdopterin MolybdenumtransferaseMpt Mo-TransferaseDomain E |
| Database Links | Reactome: R-HSA-947581 |
| Cellular Localisation | Postsynaptic Cell MembraneLipid-AnchorCytoplasmic SideCell MembraneCytoplasmCytosolCytoskeletonCell ProjectionDendritePostsynaptic DensityCytoplasmic Face Of Glycinergic Postsynaptic MembranesForms Clusters At Synapses |
| Alternative Antibody Names | Anti-Gephyrin Includes - Molybdopterin Adenylyltransferase antibodyAnti-Mpt Adenylyltransferase antibodyAnti-Domain G - Molybdopterin Molybdenumtransferase antibodyAnti-Mpt Mo-Transferase antibodyAnti-Domain E antibodyAnti-GPHN antibodyAnti-GPH antibodyAnti-KIAA1385 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
