![Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200914/413096/STJN000301-SDS-PAGE-1__43637.1749232598.jpg?c=1 "Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)")
![Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200914/413096/STJN000301-SDS-PAGE-1__43637.1749232598.jpg?c=1 "Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)")
Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Platelet Glycoprotein Vi is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1026 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | GP6 |
| Gene ID | 51206 |
| Uniprot ID | GPVI_HUMAN |
Additional Info
| Post Translational Modifications | N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). |
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. |
| Protein Name | Platelet Glycoprotein ViGpviGlycoprotein 6 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202733Reactome: R-HSA-75892 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Nanobody Names | Anti-Platelet Glycoprotein Vi nanobodyAnti-Gpvi nanobodyAnti-Glycoprotein 6 nanobodyAnti-GP6 nanobody |
Information sourced from Uniprot.org