Anti-GP6/GPVI antibody [SRM13370] (STJ11108100)

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STJ11108100
€142.20 - €625.80
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Applications:FC/ELISA
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SRM13370
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:FC, 1:500-1:1000
Formulation:PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:GP6
Gene ID:51206
Uniprot ID:GPVI_HUMAN
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Sequence:Human
Post Translational Modifications N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Protein Name Platelet Glycoprotein Vi
Gpvi
Glycoprotein 6
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-202733
Reactome: R-HSA-75892
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Membrane Protein
Isoform 2: Cell Membrane
Alternative Antibody Names Anti-Platelet Glycoprotein Vi antibody
Anti-Gpvi antibody
Anti-Glycoprotein 6 antibody
Anti-GP6 antibody

Information sourced from Uniprot.org

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